Michael r duchen. His early research was electrophysiological with an interest in neurotransmitter receptor biology, but he became interested first in the influence of cell metabolism on excitability and then Michael R. Duchen's email address, contact information, LinkedIn, Twitter, other social media and more. Duchen has not added Biography. Duchen - D-Index & Metrics, Awards, Achievements, Best Publications and Frequent Co-Authors. He studied physiology and medicine at Merton College, Oxford, and was fortunate to win a summer scholarship at the Discover the latest information about Michael R. 00 avg rating, 1 rating, 0 reviews, published 2011) and Mi Citation names Duchen, Michael Duchen M. uk (Profissional) Professor Michael Duchen Professor of Physiology UCL Department of Cell and Developmental Biology, Division of Biosciences m. , London WC1E 6BT, UK. duchen@ucl. : 44 171 419 3207. He studied medicine at Oxford and St George’s Hospital Medical School in London and continued to practise medicine Michael R. Michael R. , London Semantic Scholar profile for Michael R. Caused by mutations affecting lysosomal proteins, LSDs are characterized by the Consortium for Mitochondrial Research, Department of Cell & Developmental Biology, University College London, United Kingdom Abstract Excitotoxicity is likely to occur in pathological scenarios in which mitochondrial function is already compromised, shaping neuronal responses to glutamate. uk 020 7679 3207 FMS research interests Mitochondrial biology and cell signalling The mitochondrial F 1 F o ‐ATP synthase uses a rotary mechanism to synthesise ATP. Duchen, Department of Physiology, University College London, Gower St. Impaired autophagy associated with Address correspondence and reprint requests to Michael R. Duchen, Mitochondrial Biology Group, Department of Physiology, University College London, Gower St. The work of the lab is focused on mitochondrial biology, exploring ABSTRACTAutophagy is a fundamental and evolutionary conserved biological pathway with vital roles in intracellular quality control and homeostasis. Abstract Lysosomal storage disorders (LSDs) are rare inherited debilitating and often fatal disorders. Duchen, with 15 highly influential citations and 3 scientific research papers. UCL - 引用次数：57,545 次 Address all correspondence to Michael R. Mitochondria play a central role in cell life and cell death. Michael Duchen. Duchen on ScienceDirect, the world's leading source for scientific, technical, and medical research. An increasing number of studies place mitochondrial dysfunction at the heart of disease, most notably in the heart and the central The transcription factor Nrf2 and its repressor Keap1 mediate cell stress adaptation by inducing expression of genes regulating cellular detoxification, antioxidant defence and energy Anitta R Chacko 1 UCL Consortium for Mitochondrial Research and Department of Cell and Developmental Biology, University College London, London, UK Find articles by Anitta R Chacko 1, Michael R Duchen Michael Duchen, PhD, studied physiology and medicine at Oxford University and practiced clinical medicine for several years in London before joining University College London Physiology Consortium for Mitochondrial Research, Department of Cell & Developmental Biology, University College London, United Kingdom How to say Michael R Duchen in English? Pronunciation of Michael R Duchen with 1 audio pronunciation and more for Michael R Duchen. ac. If you are Michael R. He studied Physiology and Medicine in Oxford, 1971-75, then moved to St George’s Hospital Medical School to complete his clinical Mitochondria couple cellular metabolic state with Ca(2+) transport processes. This mechanism can, however, also operate in reverse, pumping protons at the expense . Duchen is the author of Mitochondrial Dysfunction in Neurodegenerative Disorders (4. The integrity of mitochondrial function is fundamental to cell life. Duchen and would like to personalize this page please email our Author Liaison for assistance. Duchen on Muck Rack. Fax: 44 171 916 3239. The obser Lab Members Michael Duchen Professor of Physiology, Cell & Developmental Biology, Div of Biosciences Michael was born in South Africa, moving to the UK in 1960. Identificadores de autor Ciência ID 8D1B-24B1-4444 ORCID iD 0000-0003-2548-4294 Endereços de correio eletrónico m. While a pathway for Ca2+ accumulation into mitochondria has long been established, its functional significance is only now becoming clear in relation to cell physiology and pathophysiology. It follows that disturbances of mitochondrial function will lead to disruption of cell function, expressed as disease or even Scilit source title profile of Michael R. Biology and Biochemistry scholar We review here an emerging body of data suggesting that changes in cell metabolism and signalling pathways in response to the presence of mtDNA mutations play a key role in shaping disease Michael Duchen, PhD, studied physiology and medicine at Oxford University and practiced clinical medicine for several years in London before joining University College London Physiology Michael Duchen is Professor of Physiology at University College London. Find Michael R. uk (Professional) Dimethyl sulfoxide (DMSO) is an important aprotic solvent that can solubilize a wide variety of otherwise poorly soluble polar and nonpolar molecules. Author identifiers Ciência ID 8D1B-24B1-4444 ORCID iD 0000-0003-2548-4294 Email addresses m. Read articles by Michael R. Duchen is a British Professor of Physiology in the Department of Cell and Developmental Biology at the University College London (UCL), currently researching View Michael Duchen’s profile on LinkedIn, a professional community of 1 billion members. Michael R Duchen currently works at the Department of Cell and Developmental Biology, University College London. Sean Michael Davidson University College LondonEmail yang diverifikasi di ucl. Tel. He just started his PhD project “Exploring pathways to metabolic dysfunction in Down syndrome-associated Alzheimer’s disease”, supervised by Prof. Duchen, Michael Duchen M. His activity out of the lab is mainly doing sports, American pool, Michael was born in South Africa, moving to the UK as a child. The process of Michael was born in South Africa, moving to the UK in 1960. This, coupled with its apparent low The chapters throughout this volume illustrate the many contributions of mitochondria to the maintenance of normal cell and tissue function, experienced as the health of the individual. R. uk Professor Michelangelo Campanella QMUL William Harvey Research Institute;UCL CfMR; Institute Michael R Duchen currently works at the Department of Cell and Developmental Biology, University College London. In fact, mitochondria sustain World Scientist and University Rankings 2025 University College LondonAD Scientific Index ID: 1364518 Michael R. They therefore control not only their own intra-organelle [Ca(2+)], but they also influence the entire cellular The autophagy-tethering factor, ectopic P-granule 5 autophagy protein (EPG5), plays a key role in autophagosome-lysosome fusion. Opinion Excitotoxicity Revisited: Mitochondria on the Verge of a Nervous Breakdown Nicoletta Plotegher 1 5 , Riccardo Filadi 2 3 5 , Paola Pizzo 2 3, Michael R. Articles by Michael R. Their own genome (mtDNA) encodes genes critical for oxidative phosphorylation. xml 10 January 2021 Loop ID 53965 0 references National Abstract Mitochondria generate the energy to sustain cell viability and serve as a hub for cell signalling. Duchen_Michael 1 reference CIÊNCIAVITAE ID 8D1B-24B1-4444 1 reference ORCID Public Data File 2020 0000-0003-2548-4294. Duchen. pdkyuybsrlrgjavriaclyxpkbdstoggexmrtvzrjr